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I had really bad acne in high school. I tried almost everything. Because I also have bad eczema, all that happened was burning skin. I went to the skin doctor and he prescribed isotretinoin because had taken it as a teenager and he told me that since he used it, he has had only one pimple (the one on his forehead now [he looks 45] ). So I used it. At first nothing happened then very slowly the acne was going away. All of a sudden, it seemed like my pimple hated Claravis and bonded together as gigantic unpopable wretches around my chin (during this time all the others slowly went away). Now, I only have two of those boss pimple, both in the process of being reabsorbed, and a small network of tiny pimples on my cheeks. Things are looking up.