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Overall presence of systemic lupus erythematosus, ulcerative colitis, and Crohn's disease were rare in our study population and between D25-deficient and D25 normal individuals.

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But in about 50% of patients with advanced disease, even multidrug regimens fail to suppress plasma viral RNA to undetectable levels.

The author thanks Rosemary Mazanet for reviewing the manuscript.

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Since we studied patients with both chronic kidney disease and diabetes who were not undergoing dialysis, we need to be cautious in generalizing our findings to other populations.

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