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In vivo data from a study that evaluated the co-administration of gemfibrozil and repaglinide in healthy subjects showed a significant increase in repaglinide blood levels.
Efficacy and tolerability of sitagliptin monotherapy in elderly patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.
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Therefore, dosing reduction of drugs that are mainly metabolized by CYP2C8 enzyme may be required when Gemfibrozil is used concomitantly (see WARNINGS).
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Objective: Describe the nurse's role in the pharmacologic management of renal disorders, and in diuretic therapy.
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If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop.
Similar post-prandial glycemic effects were seen between groups.
Other nursing interventions include assessing for signs and symptoms of myocardial infarction, dysrhythmias, and hepatic dysfunction during treatment.
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Even before type 2 diabetes develops, beta cell problems can be detected in glucose tolerance tests, which give abnormal test results in prediabetic individuals.
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Prospective Diabetes Study and Veterans Affairs Cooperative Study in Type 2 Diabetes trials, while frequently cited, are not representative of current treatment regimens and do not demonstrate the true frequency and risk of hypoglycemia.